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pentobarbital improves toxicity of ifosfamide by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on. CYP3A4 inducers may improve the metabolism of ifosfamide to its active alkylating metabolites.Phenobarbital appears to interfere with the absorption of orally administered griseofulvin, So reducing its blood degree.A